Antonio Conte goes into the game with the luxury of having no real injury concerns and, with the Blues being eight points clear at the top of the Premier League, the Italian could theoretically play his strongest team here.
However, with a trip to Anfield on Tuesday evening to face Liverpool, one would strongly suspect that this is a game where a number of fringe players are likely to feature. It would seem highly likely that this is a game in which the likes of Kurt Zouma, Nathan Ake, Ruben Loftus-Cheek and Nathaniel Chalobah all start.
Chelsea have won their last nine games in all competitions at Stamford Bridge and 13 of the last 14 on home turf. By comparison, Brentford are 15th in the Championship and lost 2-1 at Wigan Athletic last Saturday.
The Bees had a comfortable 5-1 win over National League Eastleigh in the 3rd round at Griffin Park, but it would probably be fair to say that they’ve not quite lived up to expectations in the Championship this term.
Bees could be lacking sting
With Brentford’s leading goalscorer Scott Hogan seemingly on the verge of a £15 million move to West Ham United, it has to doubted whether he’ll feature at Stamford Bridge, even if he hasn’t already left by then.
Hogan’s potential absence would leave the Bees looking a little lightweight in attack. Dean Smith is said to be in the market for several players himself, but whether anyone will be signed in time for Saturday would seem unlikely at this stage.
Even with a weakened starting XI, it’s difficult to see anything but a Chelsea victory here. It might take the re-jigged team a while to settle though and if, as against Peterborough United in the last round, the likes of Diego Costa and Eden Hazard are rested, they might struggle just a tad when it comes to scoring goals and creating chances.
A Chelsea Win with Under 3.5 Goals at 13/10 with bet365 looks a decent bet.